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A recent study 40 showed UA to regulate the transmission of alpha-synuclein in both animal and cellular Parkinsonian models, with a reduction in dopaminergic cell damage

138 Simultaneously, SIRT3 can not only induce the expression of antioxidant enzymes by activating the FOXO3a, but also enhance the activation of SOD2 and catalase via NAD + -dependent deacetylation

It plays a vital role in cellular migration, proliferation, and differentiation

SAM is additionally required for phosphatidylcholine synthesis, which is abundant in neuronal membranes and is crucial for synaptogenesis and neurite outgrowth ( Vitamin B12 is a cofactor for the enzyme methylmalonyl-CoA mutase, which converts methylmalonyl-CoA to succinyl-CoA, a crucial step in fatty acid metabolism (73)

60 years of dioxygen activation